Insulin-like growth factor 1 (IGF-1): a growth hormone

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Insulin-like growth factor 1 (IGF-1): a growth hormone.

AIM To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process. METHODS To describe growth in human and animal models of isolated IGF-1 deficiency (IGHD), such as in Laron syndrome (LS; primary IGF-1 deficiency and GH resistance) and IGF-1 gene or GH receptor gene knockout (KO) mice. RESULTS Since the descri...

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The Insulin-like Growth Factor-1 (IGF-1) System

Insulin-like growth factor-1 (IGF-1) has become recognized as a growth factor with pro-mitogenic and antiapoptotic effects on a variety of human cells. This article reviews the potential role of IGF-1 ligand in the clinical management of breast cancer patients. Many studies have shown that IGF-1 acts synergistically with oestrogen to stimulate breast cancer cells. Case-control studies have also...

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Growth Hormone and Insulin-Like Growth Factor-1.

Human growth hormone (GH) was first isolated from the human pituitary gland in 1945 and found to promote the growth of children with hypopituitarism. Since the formation of the World Anti-Doping Association, human GH has appeared on the list of forbidden substances. There is a significant amount of anecdotal evidence that human GH is misused by athletes to enhance performance, and there have be...

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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.

Insulin-like growth factor (IGF)-1 is an important neurotrophic hormone. Deficiency of this hormone has been reported to influence the genesis of cognitive impairment and dementia in the elderly patients. Nevertheless, there are studies indicating that cognitive function can be maintained into old age even in the absence of circulating IGF-1 and studies that link IGF-1 to an acceleration of neu...

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Effects of zinc sulfate (ZnSO4) in diet on the growth performance and gene expression of Insulin-like growth factor-1 (IGF-1) and Ghrelin in goldfish (Carassius auratus)

The zinc element (Zn) is one of the micronutrients and an essential element of the body which has some deleterious and irreparable effects on growth in case of lack it. Thus, we aimed to assess IGF-1 in goldfish with Zn deficiency and to investigate the effect of Zn supplementation on these parameters. Goldfish  (Carassius auratus)  juvenile  (3.5 g)  were fed purified diets based on casein as ...

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ژورنال

عنوان ژورنال: Molecular Pathology

سال: 2001

ISSN: 1366-8714

DOI: 10.1136/mp.54.5.311